Tomato (Solanum lycopersicum L.) is an economically important crop worldwide. In addition, tomato serves as an excellent model system for plant genetics and biology, including fruit biology, abiotic stress tolerance, and plant-microbe interactions. Development and practical use of molecular markers have been actively pursued in molecular breeding programs for tomato, especially for disease resistance to allow selection of a single resistance gene and combination of multiple resistance genes. Due to insufficient genetic variation in cultivated tomatoes, various wild relatives of tomato have been investigated and utilized as disease resistance sources. In order to pursue the resistance provided by these wild relatives in developing new tomato varieties, molecular markers have been developed and intensively utilized in tomato breeding programs. In this review, we summarize the currently available molecular markers that confer resistance against major tomato diseases, including Tomato yellow leaf curl virus (TYLCV), Tomato spotted wilt virus (TSWV), Tomato mosaic virus (ToMV), verticillium wilt, fusarium wilt, late blight caused by Phytophthora infestans, leaf mold caused by Cladosporium fulvum, root-knot caused by Meloidogyne spp., bacterial spot caused by Xanthomonas spp., and bacterial speck caused by Pseudomonas syringae. The provided marker information is expected to contribute to development of marker-assisted selection for disease resistance and to exploration of novel genetic sources for a tomato breeding program.
Citations
Citations to this article as recorded by
From Genetic Diversity to Genetic Gain: Molecular Approaches and Breeding Strategies in Tomato with Insights from Lithuanian Germplasm Audrius Radzevičius, Danguolė Juškevičienė, Jonas Viškelis, Rasa Karklelienė International Journal of Molecular Sciences.2026; 27(12): 5433. CrossRef
Molecular screening of wild and cultivated tomato germplasm reveals potential materials for multi-locus disease resistance breeding Ehtisham Hussain, Chien-yu Cheng, I-min Huang, Chen-yu Lin, Samrin Gul, Ijaz Rasool Noorka, Assaf Eybishitz, Chutchamas Kanchana-udomkan, Maarten van Zonneveld, Ya-ping Lin Genetic Resources and Crop Evolution.2025; 72(7): 8619. CrossRef
An advanced 10K SNP panel for genotyping tomato (Solanum lycopersicum L.) via targeted genome sequencing Yawo Mawunyo Nevame Adedze, Yanfen Xu, Song Liu, Yaran Zhao, Changjuan Mo, Renxu Zhang, Jiahui Dong, Haofa Lan, Jingjing Huang, Xingming Chen, Xuefei Gao, Qingzhen Yin, Jianan Zhang Frontiers in Plant Science.2025;[Epub] CrossRef
Presence of disease resistance genes in tomato germplasm revealed by gene-based or gene-linked molecular markers Luyao Yang, Jie Ren, Huanhuan Yang, Tao Zhou, Wencai Yang Molecular Breeding.2025;[Epub] CrossRef
Use of molecular markers associated with resistance to biotic and abiotic environmental factors in developing breeding material for tomato and pepper in Belarus O. G. Babak, E. V. Drozd, N. A. Nekrashevich, N. V. Anisimova, K. K. Yatsevich, P. V. Shesteren, I. Е. Bayeva, N. A. Nevestenko, I. G. Puhachova, M. M. Dobrodzkin, A. V. Kilchevsky Vegetable crops of Russia.2025; (1): 5. CrossRef
DNA-free genome editing in tomato protoplasts using CRISPR/Cas9 ribonucleoprotein delivery Ga Hui Kang, Beum-Chang Kang, Jeung-Sul Han, Je Min Lee Horticulture, Environment, and Biotechnology.2024; 65(1): 131. CrossRef
A search for tomato disease resistance genes using molecular markers to create new genotypes I. N. Shamshin, A. S. Ilyichev, M. G. Fomicheva, E. V. Grosheva Plant Biotechnology and Breeding.2024; 7(3): 19. CrossRef
Molecular and genetic basis of tomato resistance to major fungal diseases M. V. Maslova, I. N. Shamshin, E. V. Grosheva, A. S. Ilyichev Vegetable crops of Russia.2023; (6): 28. CrossRef
Seçilmiş Domatesler Arasında Genetik İlişkiler ve Bazı Patojenlere Karşı Dayanım Düzeylerinin Belirlenmesi Gülbanu KIYMACI, Ayşe Özgür UNCU, Önder TÜRKMEN Akademik Ziraat Dergisi.2023; 12(2): 177. CrossRef
The New Green Challenge in Urban Planning: The Right Genetics in the Right Place Silvia Farinati, Angelo Betto, Fabio Palumbo, Francesco Scariolo, Alessandro Vannozzi, Gianni Barcaccia Horticulturae.2022; 8(9): 761. CrossRef
Germplasm Screening Using DNA Markers and Genome-Wide Association Study for the Identification of Powdery Mildew Resistance Loci in Tomato Jiyeon Park, Siyoung Lee, Yunseo Choi, Girim Park, Seoyeon Park, Byoungil Je, Younghoon Park International Journal of Molecular Sciences.2022; 23(21): 13610. CrossRef
QTL-Seq Analysis for Identification of Resistance Loci to Bacterial Canker in Tomato Alebel Mekuriaw Abebe, Chang-Sik Oh, Hyoung Tae Kim, Giwon Choi, Eunyoung Seo, Inhwa Yeam, Je Min Lee Frontiers in Plant Science.2022;[Epub] CrossRef
Progress in Marker-Assisted Selection to Genomics-Assisted Breeding in Tomato Jagesh Kumar Tiwari, Suresh Reddy Yerasu, Nagendra Rai, Dhananjaya P. Singh, Achuit K. Singh, Suhas G. Karkute, Prabhakar M. Singh, Tusar K. Behera Critical Reviews in Plant Sciences.2022; 41(5): 321. CrossRef
Screening of pepino (Solanum muricatum) and wild relatives against four major tomato diseases threatening its expansion in the Mediterranean region Juan Pacheco, Salvador Soler, Maria R. Figàs, Alberto San Bautista, Jaime Prohens, Pietro Gramazio Annals of Applied Biology.2021; 179(3): 288. CrossRef
Evaluation of tomato (Solanum lycopersicum L.) lines and varieties to develop new breeding lines in Korea M.C. Cho, S.Y. Lee, E.Y. Yang, C.W. Nam, J.H. Moon, S.Y. Chae, J.H. Kim Acta Horticulturae.2021; (1316): 35. CrossRef
Genetic Mapping of green-stripe in Tomato Woon Cho, Eun Sol Kang, Je Min Lee Horticultural Science and Technology.2021; 39(3): 402. CrossRef
Development of codominant SCAR markers to detect the Pto, Tm22, I3 and Sw5 genes in tomato (Solanum lycopersicum) Jianbo Zhang, Dilip R. Panthee, Klaus Pillen Plant Breeding.2021; 140(2): 342. CrossRef
Characterization of tomato accessions for morphological, agronomic, fruit quality, and virus resistance traits Stanislava Grozeva, Amol N. Nankar, Daniela Ganeva, Ivanka Tringovska, Gancho Pasev, Dimitrina Kostova, Brian Beres Canadian Journal of Plant Science.2021; 101(4): 476. CrossRef
Genomics and Marker-Assisted Improvement of Vegetable Crops Ivan Simko, Mengyuan Jia, Jelli Venkatesh, Byoung-Cheorl Kang, Yiqun Weng, Gianni Barcaccia, Sergio Lanteri, Gehendra Bhattarai, Majid R. Foolad Critical Reviews in Plant Sciences.2021; 40(4): 303. CrossRef
ASSESSMENT AND APPLICATION OF MOLECULAR MARKERS IN BREEDING FOR THE RESISTANCE OF TOMATO (SOLANUM LYCOPERSICUM L.) TO LATE BLIGHT (PHYTOPHTHORA INFESTANS) O. G. Babak, E. V. Drozd, N. A. Nekrashevich, N. V. Anisimova, K. K. Yatsevich, I. E. Bayeva, A. V. Frantsuzionak, I. G. Pugachova, M. M. Dobrodkin, A. V. Kilchevsky Молекулярная и прикладная генетика.2021; 31: 22. CrossRef
Host reaction of tomato varieties and applicability of Sm-linked DNA markers to Stemphylium lycopersici Jiyeon Park, Seungahn Kwon, Girim Park, Siyoung Lee, Byoung Il Je, Younghoon Park Molecular Breeding.2020;[Epub] CrossRef
Exploring the efficacy of antagonistic rhizobacteria as native biocontrol agents against tomato plant diseases S. Karthika, Sherin Varghese, M. S. Jisha 3 Biotech.2020;[Epub] CrossRef
Combination of newly developed SNP and InDel markers for genotyping the Cf-9 locus conferring disease resistance to leaf mold disease in the tomato Boyoung Kim, In Sun Hwang, Hyung-Jin Lee, Chang-Sik Oh Molecular Breeding.2017;[Epub] CrossRef
Current advances and prospectus of viral resistance in horticultural crops Inhwa Yeam Horticulture, Environment, and Biotechnology.2016; 57(2): 113. CrossRef
Origin of the plant Tm-1-like gene via two independent horizontal transfer events and one gene fusion event Zefeng Yang, Li Liu, Huimin Fang, Pengcheng Li, Shuhui Xu, Wei Cao, Chenwu Xu, Jinling Huang, Yong Zhou Scientific Reports.2016;[Epub] CrossRef
Comparative study of effect of TYLCV and Septoria blight on F3 tomato lines Mehboob Ahmad, Zishan Gul, Mazhar Iqbal International Journal of Biosciences (IJB).2016; : 229. CrossRef
First
Prev
